PacBio Kinnex sequencing will generate full-length transcript data to help advance TychoBio’s drug discovery models PacBio Kinnex sequencing will generate full-length transcript data to help advance TychoBio’s drug discovery models
As we have entered the endemic phase of COVID-19, there is a need to assess the long-term effects of SARS-CoV-2 infection on the trajectory of neurodegenerative disorders. Herein, we investigate whether the SARS-CoV-2 RNA-binding nucleocapsid protein (NCP; N-protein) may influence molecular…
Transfer RNA (tRNA) is highly modified and difficult to profile using reverse-transcription-based sequencing. Here, we established a direct RNA sequencing (tRNA-DRS) workflow to simultaneously characterize tRNA abundance and modification signals in mouse liver. The workflow included small-RNA…
The chloroplast is a semi-autonomous organelle with a compact genome encoding ~100 expressed genes. Numerous and widespread promoters coupled with inefficient transcription termination leads to a highly complex primary transcriptome that undergoes extensive RNA quality control orchestrated by RNA…
Spatial transcriptomics is increasingly used to infer cellular phenotypes, molecular interactions, and functional tissue organization from RNA, although most of these biological processes are ultimately mediated by proteins. Here, we directly tested the interchangeability of spatial RNA and protein…
RNA-binding proteins (RBPs) are increasingly recognized to perform chromatin-associated functions in addition to their canonical roles in RNA regulation, yet how these activities are coordinated in human embryonic stem cells (hESCs) remain poorly understood. Here, we characterize distinct RNA- and…
The interferon (IFN)-inducible RNA editor ADAR1 p150 catalyzes adenosine-to-inosine (A-to-I) editing of host and viral double-stranded RNAs, limiting aberrant innate immune sensing and regulating gene expression. How ADAR1 p150 activity is regulated during host-virus interactions remains poorly…
New research shows that a non-invasive urine sample can reveal not just whether a tumor is present, but how it will respond to treatment, expanding what cell-free RNA diagnostics can do beyond detection alone. SAN CARLOS, Calif., Oct. 5, 2026 /PRNewswire/ -- Resero Bio, a precision...
The SARS-CoV-2 nucleocapsid (N) protein is a 419-amino-acid modular protein essential for viral RNA replication, genome packaging, and host-cell modulation. It contains two structured domains, the N-terminal RNA-binding domain (NTD) and C-terminal dimerization domain (CTD), separated and flanked by…
