- University / research
- Country: United States
C-terminal domain of SARS CoV 2 nucleocapsid protein binds transcriptional regulatory sequence RNA with high affinity and forms higher-order assemblies
The SARS-CoV-2 nucleocapsid (N) protein is a 419-amino-acid modular protein essential for viral RNA replication, genome packaging, and host-cell modulation. It contains two structured domains, the N-terminal RNA-binding domain (NTD) and C-terminal dimerization domain (CTD), separated and flanked by…