Spatial transcriptomics is increasingly used to infer cellular phenotypes, molecular interactions, and functional tissue organization from RNA, although most of these biological processes are ultimately mediated by proteins. Here, we directly tested the interchangeability of spatial RNA and protein…
RNA-binding proteins (RBPs) are increasingly recognized to perform chromatin-associated functions in addition to their canonical roles in RNA regulation, yet how these activities are coordinated in human embryonic stem cells (hESCs) remain poorly understood. Here, we characterize distinct RNA- and…
The interferon (IFN)-inducible RNA editor ADAR1 p150 catalyzes adenosine-to-inosine (A-to-I) editing of host and viral double-stranded RNAs, limiting aberrant innate immune sensing and regulating gene expression. How ADAR1 p150 activity is regulated during host-virus interactions remains poorly…
New research shows that a non-invasive urine sample can reveal not just whether a tumor is present, but how it will respond to treatment, expanding what cell-free RNA diagnostics can do beyond detection alone. SAN CARLOS, Calif., Oct. 5, 2026 /PRNewswire/ -- Resero Bio, a precision...
The SARS-CoV-2 nucleocapsid (N) protein is a 419-amino-acid modular protein essential for viral RNA replication, genome packaging, and host-cell modulation. It contains two structured domains, the N-terminal RNA-binding domain (NTD) and C-terminal dimerization domain (CTD), separated and flanked by…
Long non-coding RNAs (lncRNAs) are a class of regulatory RNAs with lengths exceeding 200 nucleotides. The lncRNA PURPL (p53 upregulated regulator of p53 levels) is a p53-regulated gene. PURPL is an oncogenic lncRNA that represses p53 function; it is upregulated in many tumors and promotes cancer…
Recently, spatial omics has become a powerful tool, enabling researchers to see not only what molecules are present in a tissue, but also where they are located and how they are organized across cells, tissue structures and local microenvironments. This spatial context has deepened our…
First clinical evidence demonstrating that a systemically delivered small activating RNA (saRNA) can safely upregulate an endogenous target protein in human skeletal muscle in a monogenic disease. Paired muscle biopsies reveal 3.5- to 5.3-fold increases in sarcolemmal utrophin expression,...
Scientists may have found a clue to one of the biggest mysteries surrounding the origin of life: how fragile RNA molecules could gather and survive before cells existed. New research shows that RNA is unusually good at assembling into tiny liquid-like droplets that concentrate molecules and can…
