- University / research
- Country: United States
GNG2-MRAS interaction regulates SHOC2-dependent RAF activation and MAPK signaling
Dysregulation of the mitogen-activated protein kinase (MAPK) signaling pathway is a hallmark of many human cancers and RASopathies. The SHOC2-MRAS-PP1C; (SMP) holophosphatase complex is a crucial regulatory node of this pathway. It activates the MAPK pathway by dephosphorylating the inhibitory…