Background Bone cancer pain (BCP) is a debilitating complication of advanced cancer that substantially impairs physical function and emotional wellbeing. Current pharmacological treatments often provide incomplete analgesia and may be limited by adverse effects. Shikonin, a bioactive naphthoquinone…
Pathogen infection profoundly remodels host metabolism. Whether hosts sense specific pathogen-induced metabolic changes to identify microbial infection is not known. Here, we find that depletion the monounsaturated fatty acid oleate is a metabolic pattern of pathogenesis, specifically surveilled by…
Dysregulation of the mitogen-activated protein kinase (MAPK) signaling pathway is a hallmark of many human cancers and RASopathies. The SHOC2-MRAS-PP1C; (SMP) holophosphatase complex is a crucial regulatory node of this pathway. It activates the MAPK pathway by dephosphorylating the inhibitory…
