- University / research
- Country: United States
Shikonin alleviates bone cancer pain through suppression of spinal IGF2-associated p38 MAPK signaling
Background Bone cancer pain (BCP) is a debilitating complication of advanced cancer that substantially impairs physical function and emotional wellbeing. Current pharmacological treatments often provide incomplete analgesia and may be limited by adverse effects. Shikonin, a bioactive naphthoquinone…