- University / research
- Country: United States
Genetic control couples TGFβ-independent pluripotent stem cell renewal to deterministic forward programming across germ layers
Reproducible and scalable manufacture of human induced pluripotent stem cell (hiPSC) derivatives requires control over expansion and differentiation. Transcription factor-mediated forward programming can place hiPSC differentiation under genetic control, but expansion still relies on extracellular…