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8 headlines · 2 outlets · 1882-03-24 → 2026-10-15 · Wikipedia ↗ · 🔒 Follow
Combination drug therapy is essential for tuberculosis treatment. Yet the identification of synergistic drug combinations, in which the combined efficacy is greater than the sum of the individual drugs alone, is resource intensive and restricted to existing compounds that target only a limited…
A high rate of false rifampicin resistance (RIF-R) was recently reported in paucibacillary sputum samples tested with the Xpert(R) MTB/RIF Ultra (Ultra) assay. However, 96% of the studied facilities started the test 8 - 12 hours after addition of sample reagent (SR), exceeding the manufacturers…
Bacteriophages are highly specific predators of bacterial hosts, but the molecular mechanisms governing their entry across the structurally complex mycobacterial cell envelope remain poorly defined. Utilizing a genome-wide CRISPR interference library in the model organism Mycobacterium smegmatis…
