- University / research
- Country: United States
Targeted RNA degradation of HIV-1 TAR element at 5'UTR by CRISPR-Cas13X blocks HIV-1 lytic reactivation
Human immunodeficiency virus type 1 (HIV-1) latency remains a major barrier to a cure. Here, we developed a hypercompact CRISPR-Cas13X.1 system to target the HIV-1 5' untranslated region (5'UTR), focusing on the transactivation response (TAR) RNA element required for Tat-dependent transcription.…