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Entities › org

KDM

12 headlines · 3 outlets · 2026-10-04 → 2026-10-18 · Wikipedia ↗ · 🔒 Follow

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bioRxiv · ☆
  • University / research
  • Country: United States

KDM4 inhibition alters H3K9me3 distribution and developmental responses in SETDB1-deficient embryonic stem cells

SETDB1 contributes to histone H3 lysine 9 methylation, whereas KDM4 demethylases act on H3K9 and, for KDM4A-C, H3K36. We examined whether Setdb1 status modifies responses to the KDM4-family inhibitor QC6352 in embryonic stem cells (ESCs) and embryoid bodies (EBs). QC6352 shifted Setdb1-depleted ESC…

bioRxiv · ☆
  • University / research
  • Country: United States

KDM6A Haploinsufficiency Is Insufficient to Disrupt Cochlear Structure and Auditory Function in Mouse Models of Kabuki Syndrome Type 2

Objective: Kabuki syndrome type 2 (KS2) is a rare X-linked disorder caused by pathogenic variants in KDM6A and is frequently associated with hearing impairment. Because auditory phenotypes include sensorineural, conductive, and mixed hearing loss, we examined whether Kdm6a deficiency directly…

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