- University / research
- Country: United States
ER stress-associated IRE1α signalling links impaired QPRT-dependent NAD⁺ biosynthesis to reduced oocyte competence
Oocyte quality is closely linked to metabolic and organelle homeostasis, but the mechanisms underlying naturally occurring differences in oocyte quality remain incompletely understood. Here, we identify a link between endoplasmic reticulum (ER) stress, impaired NAD biosynthesis and poor oocyte…