SMARCA4 (BRG1) is a critical ATPase subunit of canonical BAF complexes and a known long term dependency in alveolar rhabdomyosarcoma (ARMS). To define the short term consequences of SMARCA4 loss, we used a doxycycline inducible shRNA system in Rh4 cells. Doxycycline treatment produced strong…
Single-cell sequencing profiles cellular states at discrete time points, providing population-level snapshots from which developmental and disease-associated trajectories can be reconstructed. Existing optimal-transport and flow-matching approaches typically infer temporal couplings at the level of…
Social interaction in rodents can involve a dynamic interplay of approach and withdrawal movements, requiring the brain to rapidly update information about where others are and where they may intend to go. In mammals, the posterior parietal cortex (PPC) and adjacent, reciprocally-connected…
The BGL Transportation & Logistics Infrastructure Insider NEW YORK, Oct. 20, 2026 /PRNewswire/ -- After the longest freight downturn in modern trucking history, the transportation and logistics industry is reaching a long-awaited rebound. The combination of constrained capacity and...
Source-sink dynamics are defined by the interdependence of source and sink tissues and are key determinants of plant growth and productivity. This dynamic can, be altered by disease. One example is huanglongbing (HLB), a phloem-limited disease that impacts several economically important tree…
FORT WAYNE, Ind., Oct. 19, 2026 /PRNewswire/ -- Third Quarter 2026 Performance Highlights: Record steel shipments of 3.8 million tons Net sales of $6.5 billion, operating income of $1.0 billion, and net income of $756 million Adjusted EBITDA of $1.2 billion and cash flow from operations...
Leadership Promotions Supporting Steel Dynamics Long-Term Growth FORT WAYNE, Ind., Oct. 19, 2026 /PRNewswire/ -- Steel Dynamics, Inc. (NASDAQ/GS: STLD) today announced leadership promotions in support of continued long-term growth and operational excellence. "I am excited to recognize...
Spatial multi-omic technologies entail simultaneous measurement of tens-to-thousands of molecular features (e.g. RNA, protein). While cell type and state profiling is the major focus of spatial multi-omic analyses, cytoskeletal proteins are often solely utilized for cell segmentation and quality…
Hepatitis C virus (HCV) infection is strongly intertwined with host lipid metabolism and is frequently associated with hepatic steatosis, particularly in genotype-specific cases where lipid accumulation reflects direct viral effects rather than host metabolic comorbidities. Despite extensive…