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Shotgun sequencing of DNA mixtures has the potential to become an important tool in forensic genetics, particularly for degraded samples or complex mixtures. However, the analysis of shotgun-sequenced mixtures is challenged by several confounding factors, including sequencing errors, population…
Spatial transcriptomic super-resolution recovers tissue organization obscured by coarse sampling, but fitting a model to each section greatly increases computational cost and reduces practicality. We introduce ASTRA, a cross-platform pretrained model that reconstructs expression from histology and…
Motivation: Precursor microRNA (pre-miRNA) prediction is used to prioritize genomic hairpins for miRNA annotation. Published predictors are trained and evaluated on different species collections, negative sets and data partitions, making reported gains difficult to compare. Results: We introduce…
Trigger waves are positive feedback-mediated traveling waves that propagate without slowing down or diminishing in amplitude, enabling biochemical coordination over distances where diffusion alone would be insufficient. Apoptosis can spread as trigger waves of caspase activity, as demonstrated in…
The fieldwork was carried out between December 2023 and June 2025, with the aim, among others, of confirming the possible presence of the North African Gerbil (Gerbillus campestris) in Melilla. To this end, 56 camera trap stations were installed, each equipped with a camera trap. Of the total…
How endocrine states modulate local immune responses is a fundamental question in immunology. Sexual dimorphism is a striking example: females generally mount stronger immune responses than males, yet how sex hormones intersect with local signals is poorly understood. Here, we identify an…
Tissue microenvironments differ widely in nutrient composition; yet how local nutrient conditions shape epigenetic programs that direct immune cell fate is poorly understood. We identify histone lysine propionylation (Kpr) as a chromatin mechanism linking nutrient availability to T cell fate…
Interpersonal neural synchrony research using functional near-infrared spectroscopy (fNIRS) frequently relies on wavelet transform coherence (WTC) to quantify temporal correspondence between cortical signals. Yet, whether WTC reliably recovers experimentally defined differences in signal…
Single-cell RNA sequencing (scRNA-seq) studies of Alzheimer disease (AD) mouse models have proliferated across independent laboratories, brain regions, and platforms, yet the cross-study reproducibility of transcriptional signatures derived from such data remains underexplored. We reanalyzed six…
Motivation: Enrichment analysis is widely used to extract biological meanings from gene lists. However, the large number of available tools and reference libraries often make the interpretation of results challenging. Inexperienced users lack clear guidance on which datasets and terms are most…
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