- University / research
- Country: United States
Disentangling the Crabtree and Warburg effects across syngeneic non-tumor and tumor cells.
Oxidative phosphorylation (OxPhos) and substrate-level phosphorylation (SLP) are the primary biochemical mechanisms for ATP generation in mammalian cells. Increased dependency on SLP can arise from either transient (e.g., Crabtree effect) or chronic (e.g., Warburg effect) suppression of OxPhos. We…